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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DKC1
All Species:
52.42
Human Site:
Y376
Identified Species:
82.38
UniProt:
O60832
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60832
NP_001354.1
514
57674
Y376
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Chimpanzee
Pan troglodytes
XP_521345
595
65925
Y457
V
I
M
E
R
D
T
Y
P
R
S
M
C
K
G
Rhesus Macaque
Macaca mulatta
XP_001090867
597
66468
Y459
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Dog
Lupus familis
XP_549382
517
57997
Y376
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9ESX5
509
57483
Y376
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Rat
Rattus norvegicus
P40615
509
56597
Y377
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514686
519
58453
Y378
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Chicken
Gallus gallus
Q5ZJH9
516
58132
Y374
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001028279
506
56658
Y371
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O44081
508
56812
Y374
V
I
M
E
R
D
T
Y
P
R
K
W
G
L
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17919
445
50192
K319
D
D
D
I
E
V
G
K
E
I
V
I
M
S
T
Sea Urchin
Strong. purpuratus
XP_001187533
541
60439
Y369
V
I
M
E
R
D
V
Y
P
R
K
W
G
L
G
Poplar Tree
Populus trichocarpa
XP_002323264
482
54054
V356
V
V
A
K
I
K
R
V
V
M
D
R
D
T
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LD90
565
63008
Y367
V
V
M
D
R
D
T
Y
P
R
K
W
G
L
G
Baker's Yeast
Sacchar. cerevisiae
P33322
483
54686
Y346
C
I
M
E
R
D
L
Y
P
R
R
W
G
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.3
85.5
89.9
N.A.
90
83.2
N.A.
85.3
81.4
N.A.
74.7
N.A.
64.7
N.A.
58.7
64.8
Protein Similarity:
100
85.3
86
93.6
N.A.
93.1
90.8
N.A.
88.8
89.9
N.A.
85.4
N.A.
77.6
N.A.
71.4
77
P-Site Identity:
100
73.3
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
100
N.A.
0
93.3
P-Site Similarity:
100
73.3
100
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
100
N.A.
0
93.3
Percent
Protein Identity:
61.2
N.A.
N.A.
57.5
57.9
N.A.
Protein Similarity:
76.4
N.A.
N.A.
73.4
71.9
N.A.
P-Site Identity:
6.6
N.A.
N.A.
86.6
80
N.A.
P-Site Similarity:
20
N.A.
N.A.
100
86.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
7
7
7
7
0
87
0
0
0
0
7
0
7
0
0
% D
% Glu:
0
0
0
80
7
0
0
0
7
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
7
0
0
0
0
0
80
0
87
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
80
0
7
7
0
0
0
0
7
0
7
0
0
0
% I
% Lys:
0
0
0
7
0
7
0
7
0
0
74
0
0
7
0
% K
% Leu:
0
0
0
0
0
0
7
0
0
0
0
0
0
80
0
% L
% Met:
0
0
87
0
0
0
0
0
0
7
0
7
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
87
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
87
0
7
0
0
87
7
7
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% S
% Thr:
0
0
0
0
0
0
74
0
0
0
0
0
0
7
7
% T
% Val:
87
14
0
0
0
7
7
7
7
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
80
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
87
0
0
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _